Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma

High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated under phosphatidylinositol-3-kinase (PI3K) activation, enables the recruitment a...

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Detalles Bibliográficos
Autores principales: Toricelli, Mariana, Melo, Fabiana H. M., Hunger, Aline, Zanatta, Daniela, Strauss, Bryan E., Jasiulionis, Miriam G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406712/
https://www.ncbi.nlm.nih.gov/pubmed/28430130
http://dx.doi.org/10.3390/cancers9040037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406712/
https://www.ncbi.nlm.nih.gov/pubmed/28430130
http://dx.doi.org/10.3390/cancers9040037

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