Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites

Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate d...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Qigui, Xie, Lisa, Caridha, Diana, Zeng, Qiang, Zhang, Jing, Roncal, Norma, Zhang, Ping, Vuong, Chau, Potter, Brittney, Sousa, Jason, Marcsisin, Sean, Read, Lisa, Hickman, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406721/
https://www.ncbi.nlm.nih.gov/pubmed/28491482
http://dx.doi.org/10.1155/2017/7508291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406721/
https://www.ncbi.nlm.nih.gov/pubmed/28491482
http://dx.doi.org/10.1155/2017/7508291

Ejemplares similares