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Pcsk5 is required in the early cranio-cardiac mesoderm for heart development

BACKGROUND: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a...

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Detalles Bibliográficos
Autores principales: Szumska, Dorota, Cioroch, Milena, Keeling, Angela, Prat, Annik, Seidah, Nabil G., Bhattacharya, Shoumo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407003/
https://www.ncbi.nlm.nih.gov/pubmed/28446132
http://dx.doi.org/10.1186/s12861-017-0148-y