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Parathyroid Hormone Activates Phospholipase C (PLC)-Independent Protein Kinase C Signaling Pathway via Protein Kinase A (PKA)-Dependent Mechanism: A New Defined Signaling Route Would Induce Alternative Consideration to Previous Conceptions

BACKGROUND: Parathyroid hormone (PTH) is an effective anti-osteoporosis agent, after binding to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the m...

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Detalles Bibliográficos
Autores principales: Tong, Guojun, Meng, Yue, Hao, Song, Hu, Shaoyu, He, Youhua, Yan, Wenjuan, Yang, Dehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407178/
https://www.ncbi.nlm.nih.gov/pubmed/28424452
http://dx.doi.org/10.12659/MSM.903699