The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells

PURPOSE: Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium chloride has been associated with toxic effects such as “dry eye” and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. In this study, we...

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Detalles Bibliográficos
Autores principales: Datta, Sandipan, Baudouin, Christophe, Brignole-Baudouin, Francoise, Denoyer, Alexandre, Cortopassi, Gino A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407244/
https://www.ncbi.nlm.nih.gov/pubmed/28444329
http://dx.doi.org/10.1167/iovs.16-20903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407244/
https://www.ncbi.nlm.nih.gov/pubmed/28444329
http://dx.doi.org/10.1167/iovs.16-20903

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