Targeting duplex DNA with the reversible reactivity of quinone methides

DNA alkylation and crosslinking remains a common and effective strategy for anticancer chemotherapy despite its infamous lack of specificity. Coupling a reactive group to a sequence-directing component has the potential to enhance target selectivity but may suffer from premature degradation or the n...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Chengyun, Liu, Yang, Rokita, Steven E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407369/
https://www.ncbi.nlm.nih.gov/pubmed/28458944
http://dx.doi.org/10.1038/sigtrans.2016.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407369/
https://www.ncbi.nlm.nih.gov/pubmed/28458944
http://dx.doi.org/10.1038/sigtrans.2016.9

Ejemplares similares