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Targeting duplex DNA with the reversible reactivity of quinone methides
DNA alkylation and crosslinking remains a common and effective strategy for anticancer chemotherapy despite its infamous lack of specificity. Coupling a reactive group to a sequence-directing component has the potential to enhance target selectivity but may suffer from premature degradation or the n...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407369/ https://www.ncbi.nlm.nih.gov/pubmed/28458944 http://dx.doi.org/10.1038/sigtrans.2016.9 |