Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1

The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still undefined. We hypothesized that investigation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Poliakov, Eugenia, Samuel, William, Duncan, Todd, Gutierrez, Danielle B., Mata, Nathan L., Redmond, T. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407626/
https://www.ncbi.nlm.nih.gov/pubmed/28448568
http://dx.doi.org/10.1371/journal.pone.0176487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407626/
https://www.ncbi.nlm.nih.gov/pubmed/28448568
http://dx.doi.org/10.1371/journal.pone.0176487

Ejemplares similares