Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain

BACKGROUND: AYX1 is an unmodified DNA-decoy designed to reduce acute post-surgical pain and its chronification with a single intrathecal dose at the time of surgery. AYX1 inhibits the transcription factor early growth response protein 1, which is transiently induced at the time of injury and trigger...

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Detalles Bibliográficos
Autores principales: Mamet, Julien, Harris, Scott, Klukinov, Michael, Yeomans, David C, Donahue, Renee R, Taylor, Brad K, Eddinger, Kelly, Yaksh, Tony, Manning, Donald C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407669/
https://www.ncbi.nlm.nih.gov/pubmed/28394696
http://dx.doi.org/10.1177/1744806917703112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407669/
https://www.ncbi.nlm.nih.gov/pubmed/28394696
http://dx.doi.org/10.1177/1744806917703112

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