Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

BACKGROUND: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord. Because the epigenetic mechanisms are typically long-lasting, we hypothesized that analgesia could ou...

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Detalles Bibliográficos
Autores principales: Notartomaso, Serena, Mascio, Giada, Bernabucci, Matteo, Zappulla, Cristina, Scarselli, Pamela, Cannella, Milena, Imbriglio, Tiziana, Gradini, Roberto, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407675/
https://www.ncbi.nlm.nih.gov/pubmed/28326943
http://dx.doi.org/10.1177/1744806917697009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407675/
https://www.ncbi.nlm.nih.gov/pubmed/28326943
http://dx.doi.org/10.1177/1744806917697009

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