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Two epitopes responsible for the catalytic activity of heme oxygenase‐1 identified by phage display

Heme oxygenase‐1 (HO‐1) catalyzes the oxidative degradation of heme. The catalytic mechanism of the HO‐1 reaction has been determined gradually by studies of its crystal structure and HO‐1 mutants. However, the neutralizing epitopes responsible for HO‐1 activity remain elusive. Screening of a phage...

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Detalles Bibliográficos
Autores principales: Wei, Xuran, Liu, Qingjun, Gao, Yaping, Yang, Jun, Wang, Bo, Yang, Guang, Zhang, Shihui, Zhou, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407895/
https://www.ncbi.nlm.nih.gov/pubmed/28469983
http://dx.doi.org/10.1002/2211-5463.12217