Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fun...

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Autores principales: Picca, Rosaria Anna, Calvano, Cosima Damiana, Cioffi, Nicola, Palmisano, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408167/
https://www.ncbi.nlm.nih.gov/pubmed/28368330
http://dx.doi.org/10.3390/nano7040075
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author Picca, Rosaria Anna
Calvano, Cosima Damiana
Cioffi, Nicola
Palmisano, Francesco
author_facet Picca, Rosaria Anna
Calvano, Cosima Damiana
Cioffi, Nicola
Palmisano, Francesco
author_sort Picca, Rosaria Anna
collection PubMed
description Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques.
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spelling pubmed-54081672017-05-03 Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review Picca, Rosaria Anna Calvano, Cosima Damiana Cioffi, Nicola Palmisano, Francesco Nanomaterials (Basel) Review Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques. MDPI 2017-04-02 /pmc/articles/PMC5408167/ /pubmed/28368330 http://dx.doi.org/10.3390/nano7040075 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Picca, Rosaria Anna
Calvano, Cosima Damiana
Cioffi, Nicola
Palmisano, Francesco
Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title_full Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title_fullStr Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title_full_unstemmed Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title_short Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review
title_sort mechanisms of nanophase-induced desorption in ldi-ms. a short review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408167/
https://www.ncbi.nlm.nih.gov/pubmed/28368330
http://dx.doi.org/10.3390/nano7040075
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