Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways

Transforming growth factor (TGF)-β1 plays a crucial role in the epithelial-to-mesenchymal transition (EMT) in hepatocytes and hepatic stellate cells (HSC), which contributes to the pathogenesis of liver fibrosis. Melittin (MEL) is a major component of bee venom and is effective in rheumatoid arthrit...

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Detalles Bibliográficos
Autores principales: Park, Ji-Hyun, Park, Byoungduck, Park, Kwan-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408212/
https://www.ncbi.nlm.nih.gov/pubmed/28406452
http://dx.doi.org/10.3390/toxins9040138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408212/
https://www.ncbi.nlm.nih.gov/pubmed/28406452
http://dx.doi.org/10.3390/toxins9040138

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