Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease

Niemann-Pick Type C disease (NPC) is a rare metabolic disorder characterized by disruption of normal cholesterol trafficking within the cells of the body. There are no FDA approved treatments available for NPC patients. Recently, the cycloheptaglucoside 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) has s...

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Detalles Bibliográficos
Autores principales: Collins, Christopher J., Loren, Bradley P., Alam, Md Suhail, Mondjinou, Yawo, Skulsky, Joseph L., Chaplain, Cheyenne R., Haldar, Kasturi, Thompson, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408228/
https://www.ncbi.nlm.nih.gov/pubmed/28452365
http://dx.doi.org/10.1038/srep46737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408228/
https://www.ncbi.nlm.nih.gov/pubmed/28452365
http://dx.doi.org/10.1038/srep46737

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