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Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease

Niemann-Pick Type C disease (NPC) is a rare metabolic disorder characterized by disruption of normal cholesterol trafficking within the cells of the body. There are no FDA approved treatments available for NPC patients. Recently, the cycloheptaglucoside 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) has s...

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Detalles Bibliográficos
Autores principales:	Collins, Christopher J., Loren, Bradley P., Alam, Md Suhail, Mondjinou, Yawo, Skulsky, Joseph L., Chaplain, Cheyenne R., Haldar, Kasturi, Thompson, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408228/ https://www.ncbi.nlm.nih.gov/pubmed/28452365 http://dx.doi.org/10.1038/srep46737

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