Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

BACKGROUND: Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to identify potential molecular mechanisms responsible for observed side-effects....

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Detalles Bibliográficos
Autores principales: Chartier, Matthieu, Morency, Louis-Philippe, Zylber, María Inés, Najmanovich, Rafael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408384/
https://www.ncbi.nlm.nih.gov/pubmed/28449705
http://dx.doi.org/10.1186/s40360-017-0128-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408384/
https://www.ncbi.nlm.nih.gov/pubmed/28449705
http://dx.doi.org/10.1186/s40360-017-0128-7

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