Cargando…
Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
BACKGROUND: Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to identify potential molecular mechanisms responsible for observed side-effects....
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408384/ https://www.ncbi.nlm.nih.gov/pubmed/28449705 http://dx.doi.org/10.1186/s40360-017-0128-7 |