Complementary oligonucleotides regulate induced fit ligand binding in duplexed aptamers

Duplexed aptamers (DAs) are engineered by hybridizing an aptamer-complementary element (ACE, e.g. a DNA oligonucleotide) to an aptamer; to date, ACEs have been presumed to sequester the aptamer into a non-binding duplex state, in line with a conformational selection-based model of ligand binding. He...

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Detalles Bibliográficos
Autores principales: Munzar, Jeffrey D., Ng, Andy, Corrado, Mario, Juncker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408566/
https://www.ncbi.nlm.nih.gov/pubmed/28507681
http://dx.doi.org/10.1039/c6sc03993f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408566/
https://www.ncbi.nlm.nih.gov/pubmed/28507681
http://dx.doi.org/10.1039/c6sc03993f

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