SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

The heterodimeric cytokine Cardiotrophin-like Cytokine:Cytokine-like Factor-1 (CLC:CLF-1) targets the glycosylphosphatidylinositol (GPI)-anchored CNTFRα to form a trimeric complex that subsequently recruits glycoprotein 130/Leukemia Inhibitory Factor Receptor-β (gp130/LIFRβ) for signaling. Both CLC...

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Detalles Bibliográficos
Autores principales: Larsen, Jakob V., Petersen, Claus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408589/
https://www.ncbi.nlm.nih.gov/pubmed/28117780
http://dx.doi.org/10.3791/55019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408589/
https://www.ncbi.nlm.nih.gov/pubmed/28117780
http://dx.doi.org/10.3791/55019

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