Cargando…

Effect of APOL1 disease risk variants on APOL1 gene product

Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution mutation) and APOL1G2 (delet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haque, Shabirul, Patil, Gauri, Mishra, Abheepsa, Lan, Xiqian, Popik, Waldemar, Malhotra, Ashwani, Skorecki, Karl, Singhal, Pravin C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408699/ https://www.ncbi.nlm.nih.gov/pubmed/28385815 http://dx.doi.org/10.1042/BSR20160531

Ejemplares similares

APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress
por: Wen, Hongxiu, et al.
Publicado: (2018)

Apolipoprotein L1 (APOL1) Variants (Vs) a possible link between Heroin-associated Nephropathy (HAN) and HIV-associated Nephropathy (HIVAN)
por: Lan, Xiqian, et al.
Publicado: (2015)

Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes
por: Mikulak, Joanna, et al.
Publicado: (2016)

Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity
por: Kruzel-Davila, Etty, et al.
Publicado: (2021)

APOL1 polymorphism modulates sphingolipid profile of human podocytes
por: Valsecchi, Manuela, et al.
Publicado: (2020)

Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton
por: Kumar, Vinod, et al.
Publicado: (2019)

Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
por: Tzukerman, Maty, et al.
Publicado: (2022)

Transcription and translation of APOL1 variants
por: Ejaz, Samina
Publicado: (2017)

HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria
por: Kruzel-Davila, Etty, et al.
Publicado: (2021)

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice
por: Ryu, Jung-Hwa, et al.
Publicado: (2019)

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin
por: Uzureau, Sophie, et al.
Publicado: (2020)

APOL1 variants contribute to racial disparity in sepsis
por: Bird, Lucy
Publicado: (2021)

Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
por: Pell, John, et al.
Publicado: (2023)

The metabolic effects of APOL1 in humans
por: Adeva-Andany, María M., et al.
Publicado: (2023)

Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch
por: Cheatham, Amber M., et al.
Publicado: (2018)

Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys
por: Blessing, Natalya A., et al.
Publicado: (2021)

APOL1 Kidney-Risk Variants Induce Mitochondrial Fission
por: Ma, Lijun, et al.
Publicado: (2020)

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway
por: Davis, Shamara E., et al.
Publicado: (2019)

Copy Number Variation at the APOL1 Locus
por: Ruchi, Rupam, et al.
Publicado: (2015)

A Focus on APOL1 and Kidney Disease
por: Nestor, Jordan, et al.
Publicado: (2019)

APOL1-Associated Kidney Disease in Brazil
por: Riella, Cristian, et al.
Publicado: (2019)

APOL1, Acid Load, and CKD Progression
por: Pike, Mindy, et al.
Publicado: (2019)

Lessons From APOL1 Animal Models
por: Yoshida, Teruhiko, et al.
Publicado: (2021)

APOL1 and APOL1-Associated Kidney Disease: A Common Disease, an Unusual Disease Gene − Proceedings of the Henry Shavelle Professorship
por: Pollak, Martin R., et al.
Publicado: (2023)

Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease
por: McCarthy, Gizelle M., et al.
Publicado: (2021)

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense
por: Cooper, Anneli, et al.
Publicado: (2016)

Impact of APOL1 Genetic Variants on HIV-1 Infection and Disease Progression
por: An, Ping, et al.
Publicado: (2019)

Marsyas und apoll : fur flöte ünd klavier /
por: Muench, Gerhart, 1907-1988
Publicado: (1991)

APOL1 Toxin, Innate Immunity and Kidney Injury
por: Limou, Sophie, et al.
Publicado: (2015)

G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa
por: Sumaili, Ernest K, et al.
Publicado: (2018)

APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death
por: Hughson, Michael D., et al.
Publicado: (2017)

APOL1 Risk Variants and Subclinical Cardiovascular Disease in Incident Hemodialysis Patients
por: Chen, Teresa K., et al.
Publicado: (2020)

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif
por: Ultsch, Mark, et al.
Publicado: (2021)

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
por: Tzur, Shay, et al.
Publicado: (2010)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Should kidney donors be genotyped for APOL1 risk alleles?
por: Freedman, Barry I., et al.
Publicado: (2015)

Association of preeclampsia with infant APOL1 genotype in African Americans
por: Miller, Anna K., et al.
Publicado: (2020)

3448 Macrophages, APOL1 Genotype, & Immunometabolism in CVD (MAGIC
por: Blazer, Ashira D., et al.
Publicado: (2019)

APOL1 promotes endothelial cell activation beyond the glomerulus
por: Carracedo, Miguel, et al.
Publicado: (2023)

Sequencing rare and common APOL1 coding variants to determine kidney disease risk
por: Limou, Sophie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aujd31cblim4102ajg6ra15he8