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A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a mosaic pattern at the base of the crypt. How the underlying regulatory scheme manages this dynamic stem...

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Detalles Bibliográficos
Autores principales: Chen, Kai‐Yuan, Srinivasan, Tara, Tung, Kuei‐Ling, Belmonte, Julio M, Wang, Lihua, Murthy, Preetish Kadur Lakshminarasimha, Choi, Jiahn, Rakhilin, Nikolai, King, Sarah, Varanko, Anastasia Kristine, Witherspoon, Mavee, Nishimura, Nozomi, Glazier, James A, Lipkin, Steven M, Bu, Pengcheng, Shen, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408779/
https://www.ncbi.nlm.nih.gov/pubmed/28455349
http://dx.doi.org/10.15252/msb.20167324