Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only

Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identifie...

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Detalles Bibliográficos
Autores principales: Ludwig, Kerstin U., Böhmer, Anne C., Bowes, John, Nikolić, Miloš, Ishorst, Nina, Wyatt, Niki, Hammond, Nigel L., Gölz, Lina, Thieme, Frederic, Barth, Sandra, Schuenke, Hannah, Klamt, Johanna, Spielmann, Malte, Aldhorae, Khalid, Rojas-Martinez, Augusto, Nöthen, Markus M., Rada-Iglesias, Alvaro, Dixon, Michael J., Knapp, Michael, Mangold, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409059/
https://www.ncbi.nlm.nih.gov/pubmed/28087736
http://dx.doi.org/10.1093/hmg/ddx012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409059/
https://www.ncbi.nlm.nih.gov/pubmed/28087736
http://dx.doi.org/10.1093/hmg/ddx012

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