Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain

HSJ1 (DNAJB2), a member of the DNAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance. It binds ubiquitylated proteins through its Ubiquitin Interacting Motifs (UIMs) and facilitates their delivery to the proteasome for degradation. Mutations in the DNAJB2 gene lea...

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Detalles Bibliográficos
Autores principales: Ottaviani, Daniele, Marin, Oriano, Arrigoni, Giorgio, Franchin, Cinzia, Vilardell, Jordi, Sandre, Michele, Li, Wenwen, Parfitt, David A., Pinna, Lorenzo A., Cheetham, Michael E., Ruzzene, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409130/
https://www.ncbi.nlm.nih.gov/pubmed/28031292
http://dx.doi.org/10.1093/hmg/ddw420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409130/
https://www.ncbi.nlm.nih.gov/pubmed/28031292
http://dx.doi.org/10.1093/hmg/ddw420

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