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Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4

D4Z4 repeats are present in at least 11 different mammalian species, including humans and mice. Each repeat contains an open reading frame encoding a double homeodomain (DUX) family transcription factor. Aberrant expression of the D4Z4 ORF called DUX4 is associated with the pathogenesis of Facioscap...

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Detalles Bibliográficos
Autores principales: Eidahl, Jocelyn O., Giesige, Carlee R., Domire, Jacqueline S., Wallace, Lindsay M., Fowler, Allison M., Guckes, Susan M., Garwick-Coppens, Sara E., Labhart, Paul, Harper, Scott Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409219/
https://www.ncbi.nlm.nih.gov/pubmed/28173143
http://dx.doi.org/10.1093/hmg/ddw287