Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST

Clinical phenotypes of spinocerebellar ataxia type-5 (SCA5) and spectrin-associated autosomal recessive cerebellar ataxia type-1 (SPARCA1) are mirrored in mice lacking β-III spectrin (β-III(-/-)). One function of β-III spectrin is the stabilization of the Purkinje cell-specific glutamate transporter...

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Detalles Bibliográficos
Autores principales: Perkins, Emma M., Suminaite, Daumante, Clarkson, Yvonne L., Lee, Sin Kwan, Lyndon, Alastair R., Rothstein, Jeffrey D., Wyllie, David J.A., Tanaka, Kohichi, Jackson, Mandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409221/
https://www.ncbi.nlm.nih.gov/pubmed/28173092
http://dx.doi.org/10.1093/hmg/ddw274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409221/
https://www.ncbi.nlm.nih.gov/pubmed/28173092
http://dx.doi.org/10.1093/hmg/ddw274

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