Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

The glucagon-like peptide-1 receptor (GLP-1R) is a key therapeutic target in the management of type II diabetes mellitus, with actions including regulation of insulin biosynthesis and secretion, promotion of satiety, and preservation of β-cell mass. Like most class B G protein-coupled receptors (GPC...

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Detalles Bibliográficos
Autores principales: Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409479/
https://www.ncbi.nlm.nih.gov/pubmed/28283573
http://dx.doi.org/10.1074/jbc.M117.779496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409479/
https://www.ncbi.nlm.nih.gov/pubmed/28283573
http://dx.doi.org/10.1074/jbc.M117.779496

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