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The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials

Starch digestibility may have an effect on the postprandial blood glucose profile. The aim of this meta-analysis was to analyze the relationship between Slowly Digestible Starch (SDS) levels and plasma glucose appearance and disappearance rates, as well as other parameters of glucose metabolism, aft...

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Autores principales: Vinoy, Sophie, Meynier, Alexandra, Goux, Aurélie, Jourdan-Salloum, Nathalie, Normand, Sylvie, Rabasa-Lhoret, Rémi, Brack, Olivier, Nazare, Julie-Anne, Péronnet, François, Laville, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409657/
https://www.ncbi.nlm.nih.gov/pubmed/28333086
http://dx.doi.org/10.3390/nu9040318
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author Vinoy, Sophie
Meynier, Alexandra
Goux, Aurélie
Jourdan-Salloum, Nathalie
Normand, Sylvie
Rabasa-Lhoret, Rémi
Brack, Olivier
Nazare, Julie-Anne
Péronnet, François
Laville, Martine
author_facet Vinoy, Sophie
Meynier, Alexandra
Goux, Aurélie
Jourdan-Salloum, Nathalie
Normand, Sylvie
Rabasa-Lhoret, Rémi
Brack, Olivier
Nazare, Julie-Anne
Péronnet, François
Laville, Martine
author_sort Vinoy, Sophie
collection PubMed
description Starch digestibility may have an effect on the postprandial blood glucose profile. The aim of this meta-analysis was to analyze the relationship between Slowly Digestible Starch (SDS) levels and plasma glucose appearance and disappearance rates, as well as other parameters of glucose metabolism, after healthy subjects consumed cereal products that differed in SDS content. Three randomized controlled clinical trials that included a total of 79 subjects were identified. Using binary classification for the variables (high versus low levels, more than 12 g of SDS per portion, and less than 1 g of SDS per portion, respectively), we found that there was a 15-fold higher chance of having a low rate of appearance of exogenous glucose (RaE) after consumption of a high-SDS product. A high SDS content was also associated with a 12-fold and 4-fold higher chance of having a low rate of disappearance of exogenous glucose (RdE) and rate of disappearance of total plasma glucose (RdT), respectively. The RaE kinetics were further analyzed by modeling the contribution of SDS content to the different phases of the RaE response. We show that the higher the SDS content per portion of cereal product, the higher its contribution to the incremental area under the curve (iAUC) of the RaE response after 165 min. Using the association rule technique, we found that glycemic iAUC and insulinemic iAUC values vary in the same direction. In conclusion, this meta-analysis confirms the effect of the SDS level in cereal products on the metabolic response, and shows for the first time that the degree to which SDS affects the RaE response differs depending on the SDS content of the food product, as well as the phase of the postprandial period.
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spelling pubmed-54096572017-05-03 The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials Vinoy, Sophie Meynier, Alexandra Goux, Aurélie Jourdan-Salloum, Nathalie Normand, Sylvie Rabasa-Lhoret, Rémi Brack, Olivier Nazare, Julie-Anne Péronnet, François Laville, Martine Nutrients Review Starch digestibility may have an effect on the postprandial blood glucose profile. The aim of this meta-analysis was to analyze the relationship between Slowly Digestible Starch (SDS) levels and plasma glucose appearance and disappearance rates, as well as other parameters of glucose metabolism, after healthy subjects consumed cereal products that differed in SDS content. Three randomized controlled clinical trials that included a total of 79 subjects were identified. Using binary classification for the variables (high versus low levels, more than 12 g of SDS per portion, and less than 1 g of SDS per portion, respectively), we found that there was a 15-fold higher chance of having a low rate of appearance of exogenous glucose (RaE) after consumption of a high-SDS product. A high SDS content was also associated with a 12-fold and 4-fold higher chance of having a low rate of disappearance of exogenous glucose (RdE) and rate of disappearance of total plasma glucose (RdT), respectively. The RaE kinetics were further analyzed by modeling the contribution of SDS content to the different phases of the RaE response. We show that the higher the SDS content per portion of cereal product, the higher its contribution to the incremental area under the curve (iAUC) of the RaE response after 165 min. Using the association rule technique, we found that glycemic iAUC and insulinemic iAUC values vary in the same direction. In conclusion, this meta-analysis confirms the effect of the SDS level in cereal products on the metabolic response, and shows for the first time that the degree to which SDS affects the RaE response differs depending on the SDS content of the food product, as well as the phase of the postprandial period. MDPI 2017-03-23 /pmc/articles/PMC5409657/ /pubmed/28333086 http://dx.doi.org/10.3390/nu9040318 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vinoy, Sophie
Meynier, Alexandra
Goux, Aurélie
Jourdan-Salloum, Nathalie
Normand, Sylvie
Rabasa-Lhoret, Rémi
Brack, Olivier
Nazare, Julie-Anne
Péronnet, François
Laville, Martine
The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title_full The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title_fullStr The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title_short The Effect of a Breakfast Rich in Slowly Digestible Starch on Glucose Metabolism: A Statistical Meta-Analysis of Randomized Controlled Trials
title_sort effect of a breakfast rich in slowly digestible starch on glucose metabolism: a statistical meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409657/
https://www.ncbi.nlm.nih.gov/pubmed/28333086
http://dx.doi.org/10.3390/nu9040318
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