Cargando…
Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study
The associations of glucose, fructose, and sucrose intake with type 2 diabetes mellitus (T2DM) have been inconsistent. Furthermore, there is a lack of studies focusing on early markers of T2DM that provide insight into the process of T2DM progression: impaired pancreatic β-cell function (BCF) and in...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409719/ https://www.ncbi.nlm.nih.gov/pubmed/28406435 http://dx.doi.org/10.3390/nu9040380 |
_version_ | 1783232530839764992 |
---|---|
author | den Biggelaar, Louise J. C. J. Eussen, Simone J. P. M. Sep, Simone J. S. Mari, Andrea Ferrannini, Ele van Dongen, Martien C. J. M. Denissen, Karlijn F. M. Wijckmans, Nicole E. G. Schram, Miranda T. van der Kallen, Carla J. Koster, Annemarie Schaper, Nicolaas Henry, Ronald M. A. Stehouwer, Coen D. A. Dagnelie, Pieter C. |
author_facet | den Biggelaar, Louise J. C. J. Eussen, Simone J. P. M. Sep, Simone J. S. Mari, Andrea Ferrannini, Ele van Dongen, Martien C. J. M. Denissen, Karlijn F. M. Wijckmans, Nicole E. G. Schram, Miranda T. van der Kallen, Carla J. Koster, Annemarie Schaper, Nicolaas Henry, Ronald M. A. Stehouwer, Coen D. A. Dagnelie, Pieter C. |
author_sort | den Biggelaar, Louise J. C. J. |
collection | PubMed |
description | The associations of glucose, fructose, and sucrose intake with type 2 diabetes mellitus (T2DM) have been inconsistent. Furthermore, there is a lack of studies focusing on early markers of T2DM that provide insight into the process of T2DM progression: impaired pancreatic β-cell function (BCF) and insulin sensitivity. This study evaluated associations cross-sectionally in a population-based cohort consisting of 2818 individuals (mean ± SD age 59.7 ± 8.18, 49.5% male, n = 120 newly diagnosed T2DM). Glucose, fructose, and sucrose intake were assessed by a food frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-points oral glucose tolerance test. Linear regression analysis revealed a positive association of glucose intake with insulin sensitivity in the fully adjusted model (standardized beta (95% CI) 0.07 (0.05, 0.14) SD for ≥23 g vs. <10 g of glucose). Fructose and sucrose intake were not associated with insulin sensitivity after full adjustments. In addition, no associations of dietary glucose, fructose, and sucrose with BCF were detected. In conclusion, higher intake of glucose, not fructose and sucrose, was associated with higher insulin sensitivity, independent of dietary fibre. No convincing evidence was found for associations of dietary glucose, fructose, and sucrose with BCF in this middle-aged population. |
format | Online Article Text |
id | pubmed-5409719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54097192017-05-03 Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study den Biggelaar, Louise J. C. J. Eussen, Simone J. P. M. Sep, Simone J. S. Mari, Andrea Ferrannini, Ele van Dongen, Martien C. J. M. Denissen, Karlijn F. M. Wijckmans, Nicole E. G. Schram, Miranda T. van der Kallen, Carla J. Koster, Annemarie Schaper, Nicolaas Henry, Ronald M. A. Stehouwer, Coen D. A. Dagnelie, Pieter C. Nutrients Article The associations of glucose, fructose, and sucrose intake with type 2 diabetes mellitus (T2DM) have been inconsistent. Furthermore, there is a lack of studies focusing on early markers of T2DM that provide insight into the process of T2DM progression: impaired pancreatic β-cell function (BCF) and insulin sensitivity. This study evaluated associations cross-sectionally in a population-based cohort consisting of 2818 individuals (mean ± SD age 59.7 ± 8.18, 49.5% male, n = 120 newly diagnosed T2DM). Glucose, fructose, and sucrose intake were assessed by a food frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-points oral glucose tolerance test. Linear regression analysis revealed a positive association of glucose intake with insulin sensitivity in the fully adjusted model (standardized beta (95% CI) 0.07 (0.05, 0.14) SD for ≥23 g vs. <10 g of glucose). Fructose and sucrose intake were not associated with insulin sensitivity after full adjustments. In addition, no associations of dietary glucose, fructose, and sucrose with BCF were detected. In conclusion, higher intake of glucose, not fructose and sucrose, was associated with higher insulin sensitivity, independent of dietary fibre. No convincing evidence was found for associations of dietary glucose, fructose, and sucrose with BCF in this middle-aged population. MDPI 2017-04-13 /pmc/articles/PMC5409719/ /pubmed/28406435 http://dx.doi.org/10.3390/nu9040380 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article den Biggelaar, Louise J. C. J. Eussen, Simone J. P. M. Sep, Simone J. S. Mari, Andrea Ferrannini, Ele van Dongen, Martien C. J. M. Denissen, Karlijn F. M. Wijckmans, Nicole E. G. Schram, Miranda T. van der Kallen, Carla J. Koster, Annemarie Schaper, Nicolaas Henry, Ronald M. A. Stehouwer, Coen D. A. Dagnelie, Pieter C. Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title | Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title_full | Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title_fullStr | Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title_full_unstemmed | Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title_short | Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study |
title_sort | associations of dietary glucose, fructose, and sucrose with β-cell function, insulin sensitivity, and type 2 diabetes in the maastricht study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409719/ https://www.ncbi.nlm.nih.gov/pubmed/28406435 http://dx.doi.org/10.3390/nu9040380 |
work_keys_str_mv | AT denbiggelaarlouisejcj associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT eussensimonejpm associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT sepsimonejs associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT mariandrea associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT ferranniniele associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT vandongenmartiencjm associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT denissenkarlijnfm associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT wijckmansnicoleeg associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT schrammirandat associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT vanderkallencarlaj associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT kosterannemarie associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT schapernicolaas associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT henryronaldma associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT stehouwercoenda associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy AT dagneliepieterc associationsofdietaryglucosefructoseandsucrosewithbcellfunctioninsulinsensitivityandtype2diabetesinthemaastrichtstudy |