A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded breaks (DSBs) in murine macrophage genomic DNA. I...

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Detalles Bibliográficos
Autores principales: Morales, Abigail J, Carrero, Javier A, Hung, Putzer J, Tubbs, Anthony T, Andrews, Jared M, Edelson, Brian T, Calderon, Boris, Innes, Cynthia L, Paules, Richard S, Payton, Jacqueline E, Sleckman, Barry P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409825/
https://www.ncbi.nlm.nih.gov/pubmed/28362262
http://dx.doi.org/10.7554/eLife.24655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409825/
https://www.ncbi.nlm.nih.gov/pubmed/28362262
http://dx.doi.org/10.7554/eLife.24655

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