Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity

Genes targeted by Polycomb repressive complex 2 (PRC2) are regulated in cis by chromatin modifications and also in trans by diffusible regulators such as transcription factors. Here, we introduce a mathematical model in which transcription directly antagonizes Polycomb silencing, thereby linking the...

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Detalles Bibliográficos
Autores principales: Berry, Scott, Dean, Caroline, Howard, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Math | Bio
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409831/
https://www.ncbi.nlm.nih.gov/pubmed/28342717
http://dx.doi.org/10.1016/j.cels.2017.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409831/
https://www.ncbi.nlm.nih.gov/pubmed/28342717
http://dx.doi.org/10.1016/j.cels.2017.02.013

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