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Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli

BACKGROUND: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal metalloprote...

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Detalles Bibliográficos
Autores principales: Lee, Ki Baek, Nam, Dong Hyun, Nuhn, Jacob A. M., Wang, Juan, Schneider, Ian C., Ge, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410052/
https://www.ncbi.nlm.nih.gov/pubmed/28454584
http://dx.doi.org/10.1186/s12934-017-0686-9