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Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli
BACKGROUND: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal metalloprote...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410052/ https://www.ncbi.nlm.nih.gov/pubmed/28454584 http://dx.doi.org/10.1186/s12934-017-0686-9 |