CUL-2(LRR-1) and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis

Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (Cdc45-MCM-GINS). Using Caenorhabditis elegans early embryos and Xenopus egg extracts, we show that the E3 ligase CUL-2(LRR-1) associates with th...

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Detalles Bibliográficos
Autores principales: Sonneville, Remi, Priego Moreno, Sara, Knebel, Axel, Johnson, Clare, Hastie, C. James, Gartner, Anton, Gambus, Agnieszka, Labib, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410169/
https://www.ncbi.nlm.nih.gov/pubmed/28368371
http://dx.doi.org/10.1038/ncb3500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410169/
https://www.ncbi.nlm.nih.gov/pubmed/28368371
http://dx.doi.org/10.1038/ncb3500

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