Cargando…

CUL-2(LRR-1) and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis

Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (Cdc45-MCM-GINS). Using Caenorhabditis elegans early embryos and Xenopus egg extracts, we show that the E3 ligase CUL-2(LRR-1) associates with th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sonneville, Remi, Priego Moreno, Sara, Knebel, Axel, Johnson, Clare, Hastie, C. James, Gartner, Anton, Gambus, Agnieszka, Labib, Karim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410169/ https://www.ncbi.nlm.nih.gov/pubmed/28368371 http://dx.doi.org/10.1038/ncb3500

Ejemplares similares

TIMELESS‐TIPIN and UBXN‐3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans
por: Xia, Yisui, et al.
Publicado: (2021)

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase
por: Tarcan, Zeynep, et al.
Publicado: (2022)

Mechanisms of eukaryotic replisome disassembly
por: Moreno, Sara Priego, et al.
Publicado: (2020)

LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components
por: Fan, Yilin, et al.
Publicado: (2021)

Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
por: Priego Moreno, Sara, et al.
Publicado: (2019)

CUL2(LRR1), TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle
por: Villa, Fabrizio, et al.
Publicado: (2021)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
por: Sonneville, Remi, et al.
Publicado: (2019)

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
por: Franz, André, et al.
Publicado: (2016)

Erratum: Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
por: Franz, André, et al.
Publicado: (2016)

A conserved mechanism for regulating replisome disassembly in eukaryotes
por: Jenkyn-Bedford, Michael, et al.
Publicado: (2021)

Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes
por: Le, Thanh Thi, et al.
Publicado: (2021)

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase
por: Maculins, Timurs, et al.
Publicado: (2015)

CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination
por: Dewar, James M., et al.
Publicado: (2017)

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
por: Deegan, Tom D, et al.
Publicado: (2020)

The Fate of Two Unstoppable Trains After Arriving Destination: Replisome Disassembly During DNA Replication Termination
por: Xia, Yisui
Publicado: (2021)

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
por: Hong, Ye, et al.
Publicado: (2018)

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation
por: Bandau, Susanne, et al.
Publicado: (2012)

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis
por: de Castro, Ines J, et al.
Publicado: (2017)

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids
por: Cui, Shaojie, et al.
Publicado: (2022)

Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1
por: Weber, Georg F.
Publicado: (2015)

The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A
por: Kress, Elsa, et al.
Publicado: (2013)

A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome
por: Kilkenny, Mairi L., et al.
Publicado: (2012)

Bub1 kinase in the regulation of mitosis
por: Kim, Taekyung, et al.
Publicado: (2021)

Reduced FAF1 Expression and Helicobacter Infection: Correlations with Clinicopathological Features in Gastric Cancer
por: Liu, Ai-qun, et al.
Publicado: (2012)

Termination of DNA replication forks: “Breaking up is hard to do”
por: Bailey, Rachael, et al.
Publicado: (2015)

FAF-Drugs: free ADME/tox filtering of compound collections
por: Miteva, Maria A., et al.
Publicado: (2006)

UBXN1 is a strong candidate gene in regulation of pork water-holding capacity
por: He, Jiawen, et al.
Publicado: (2021)

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos
por: Sonneville, Remi, et al.
Publicado: (2015)

USP7 and VCP(FAF1) define the SUMO/Ubiquitin landscape at the DNA replication fork
por: Franz, André, et al.
Publicado: (2021)

UBXN1 interacts with the S1 protein of transmissible gastroenteritis coronavirus and plays a role in viral replication
por: Yuan, Peng, et al.
Publicado: (2019)

RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly
por: Swaminathan, Sowmya, et al.
Publicado: (2004)

The Proto-Oncogene Int6 Is Essential for Neddylation of Cul1 and Cul3 in Drosophila
por: Rencus-Lazar, Sigal, et al.
Publicado: (2008)

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
por: Yu, Qing, et al.
Publicado: (2020)

ARRDC4 and UBXN1: Novel Target Genes Correlated with Prostate Cancer Gleason Score
por: Oh, Jong Jin, et al.
Publicado: (2021)

An MBoC Favorite: Force generation by microtubule assembly/disassembly in mitosis and related movements
por: Walczak, Claire E.
Publicado: (2012)

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis
por: Plotnikova, Olga V., et al.
Publicado: (2012)

Dynamic Alterations to α-Actinin Accompanying Sarcomere Disassembly and Reassembly during Cardiomyocyte Mitosis
por: Fan, Xiaohu, et al.
Publicado: (2015)

The Inability to Disassemble Rad51 Nucleoprotein Filaments Leads to Aberrant Mitosis and Cell Death
por: Andriuskevicius, Tadas, et al.
Publicado: (2023)

FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth
por: Gao, Fei‐Fei, et al.
Publicado: (2021)

Identification and characterization of the LRR repeats in plant LRR-RLKs
por: Chen, Tianshu
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9ov3am1nv0gj07k927e7fuiufl