Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations

Aging is associated with significant changes in hematopoiesis, including clonal dominance, anemia, myeloid malignancies, and reduced activation of signal transducer and activator of transcription 5 (Stat5). In previous studies, Stat5 deletion surprisingly amplified FLT3/ITD(+) myeloid expansion or M...

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Detalles Bibliográficos
Autores principales: Wang, Zhengqi, Bunting, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410237/
https://www.ncbi.nlm.nih.gov/pubmed/28390194
http://dx.doi.org/10.18632/oncotarget.15236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410237/
https://www.ncbi.nlm.nih.gov/pubmed/28390194
http://dx.doi.org/10.18632/oncotarget.15236

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