AvidinOX-anchored biotinylated trastuzumab and pertuzumab induce down-modulation of ErbB2 and tumor cell death at concentrations order of magnitude lower than not-anchored antibodies

The oxidized version of Avidin, known as AvidinOX, was previously shown to link to tissue proteins upon injection or nebulization, thus becoming a stable receptor for biotinylated therapeutics. AvidinOX is currently under clinical investigation to target radioactive biotin to inoperable tumor lesion...

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Detalles Bibliográficos
Autores principales: Milazzo, Ferdinando Maria, Anastasi, Anna Maria, Chiapparino, Caterina, Rosi, Antonio, Leoni, Barbara, Vesci, Loredana, Petronzelli, Fiorella, Santis, Rita De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410247/
https://www.ncbi.nlm.nih.gov/pubmed/28186982
http://dx.doi.org/10.18632/oncotarget.15145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410247/
https://www.ncbi.nlm.nih.gov/pubmed/28186982
http://dx.doi.org/10.18632/oncotarget.15145

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