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Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress

Endoplasmic reticulum (ER) in eukaryotes is a main organelle involved in a wide variety of functions including calcium storage, lipid biosynthesis, protein folding and protein transport. Disruption of ER homeostasis leads to ER stress and activation of the unfolded protein response (UPR). We and oth...

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Detalles Bibliográficos
Autores principales: Shah, Parag P., Dupre, Tess V., Siskind, Leah J., Beverly, Levi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410250/
https://www.ncbi.nlm.nih.gov/pubmed/28186986
http://dx.doi.org/10.18632/oncotarget.15150