A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel

Notch signaling pathway is an embryonic program that becomes reactivated in pancreatic cancer and contributes to cancer stem cell (CSC) maintenance. We explored the concept of oncolytic adenoviral activity in response to Notch activation signaling, in the context of a chimeric promoter with uPAR reg...

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Detalles Bibliográficos
Autores principales: Mato-Berciano, Ana, Raimondi, Giulia, Maliandi, Maria Victoria, Alemany, Ramon, Montoliu, Lluis, Fillat, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410256/
https://www.ncbi.nlm.nih.gov/pubmed/28186974
http://dx.doi.org/10.18632/oncotarget.15169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410256/
https://www.ncbi.nlm.nih.gov/pubmed/28186974
http://dx.doi.org/10.18632/oncotarget.15169

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