PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines

B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph(+)) B-ALL is a subtype that expresses the Bcr-Abl fusion protein which represents a negative prognostic factor. Constitutive activati...

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Detalles Bibliográficos
Autores principales: Ultimo, Simona, Simioni, Carolina, Martelli, Alberto M., Zauli, Giorgio, Evangelisti, Camilla, Celeghini, Claudio, McCubrey, James A., Marisi, Giorgia, Ulivi, Paola, Capitani, Silvano, Neri, Luca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410298/
https://www.ncbi.nlm.nih.gov/pubmed/28390196
http://dx.doi.org/10.18632/oncotarget.15542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410298/
https://www.ncbi.nlm.nih.gov/pubmed/28390196
http://dx.doi.org/10.18632/oncotarget.15542

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