Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest

Hyper-activation of PAK1 (p21-activated kinase 1) is frequently observed in human cancer and speculated as a target of novel anti-tumor drug. In previous, we also showed that PAK1 is highly activated in the Smad4-deficient condition and suppresses PUMA (p53 upregulated modulator of apoptosis) throug...

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Detalles Bibliográficos
Autores principales: Woo, Tae-Gyun, Yoon, Min-Ho, Hong, Shin-Deok, Choi, Jiyun, Ha, Nam-Chul, Sun, Hokeun, Park, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410337/
https://www.ncbi.nlm.nih.gov/pubmed/28423593
http://dx.doi.org/10.18632/oncotarget.15783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410337/
https://www.ncbi.nlm.nih.gov/pubmed/28423593
http://dx.doi.org/10.18632/oncotarget.15783

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