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Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression

Natural Killer (NK) cells play a critical role against tumor cells in hematological malignancies. Their activating receptors are essential in tumor cell killing. In Multiple Myeloma (MM) patients, NK cell differentiation, activation and cytotoxic potential are strongly impaired leading to MM escape...

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Detalles Bibliográficos
Autores principales: Giuliani, Massimo, Janji, Bassam, Berchem, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410361/
https://www.ncbi.nlm.nih.gov/pubmed/28199990
http://dx.doi.org/10.18632/oncotarget.15234