Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children
PURPOSE: The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD. METHODS: Serum PCT levels were examined in febrile pedi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Pediatric Society
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410617/ https://www.ncbi.nlm.nih.gov/pubmed/28461824 http://dx.doi.org/10.3345/kjp.2017.60.4.112 |
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author | Lee, Na Hyun Choi, Hee Joung Kim, Yeo Hyang |
author_facet | Lee, Na Hyun Choi, Hee Joung Kim, Yeo Hyang |
author_sort | Lee, Na Hyun |
collection | PubMed |
description | PURPOSE: The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD. METHODS: Serum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections. RESULTS: The mean PCT level in the KD group was significantly lower than that in the bacterial infection group (0.82±1.73 ng/mL vs. 3.11±6.10 ng/mL, P=0.002) and insignificantly different from that in the viral infection group (0.23±0.34 ng/mL,P=0.457). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in the KD group were significantly higher than those in the viral and bacterial infection groups (P<0.001 and P<0.001 for ESR, P<0.001 and P=0.005 for CRP, respectively). The proportion of patients in the KD group with PCT levels of >1.0 ng/mL was significantly higher in the nonresponders to the initial intravenous immunoglobulin treatment than in the responders (36% vs. 8%, P=0.01). CONCLUSION: PCT levels may help to differentiate KD from bacterial infections. A combination of disease markers, including ESR, CRP, and PCT, may be useful for differentiating between KD and viral/bacterial infections. |
format | Online Article Text |
id | pubmed-5410617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-54106172017-05-01 Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children Lee, Na Hyun Choi, Hee Joung Kim, Yeo Hyang Korean J Pediatr Original Article PURPOSE: The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD. METHODS: Serum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections. RESULTS: The mean PCT level in the KD group was significantly lower than that in the bacterial infection group (0.82±1.73 ng/mL vs. 3.11±6.10 ng/mL, P=0.002) and insignificantly different from that in the viral infection group (0.23±0.34 ng/mL,P=0.457). The mean erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in the KD group were significantly higher than those in the viral and bacterial infection groups (P<0.001 and P<0.001 for ESR, P<0.001 and P=0.005 for CRP, respectively). The proportion of patients in the KD group with PCT levels of >1.0 ng/mL was significantly higher in the nonresponders to the initial intravenous immunoglobulin treatment than in the responders (36% vs. 8%, P=0.01). CONCLUSION: PCT levels may help to differentiate KD from bacterial infections. A combination of disease markers, including ESR, CRP, and PCT, may be useful for differentiating between KD and viral/bacterial infections. The Korean Pediatric Society 2017-04 2017-04-25 /pmc/articles/PMC5410617/ /pubmed/28461824 http://dx.doi.org/10.3345/kjp.2017.60.4.112 Text en Copyright © 2017 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Na Hyun Choi, Hee Joung Kim, Yeo Hyang Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title_full | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title_fullStr | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title_full_unstemmed | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title_short | Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children |
title_sort | clinical usefulness of serum procalcitonin level in distinguishing between kawasaki disease and other infections in febrile children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410617/ https://www.ncbi.nlm.nih.gov/pubmed/28461824 http://dx.doi.org/10.3345/kjp.2017.60.4.112 |
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