Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve Autologous Stem Cells In Vivo

The duration of post-sepsis long-term immune suppression is poorly understood. Here, we focused on the role of monocytes (MO) as the pivotal cells for long-term regulation of post-sepsis milieu. Lost ability of MO to adapt is seen in several acute conditions, but it is unclear for how long MO aberra...

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Detalles Bibliográficos
Autores principales: Lapko, Natalia, Zawadka, Mateusz, Polosak, Jacek, Worthen, George S., Danet-Desnoyers, Gwenn, Puzianowska-Kuźnicka, Monika, Laudanski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410640/
https://www.ncbi.nlm.nih.gov/pubmed/28507543
http://dx.doi.org/10.3389/fimmu.2017.00401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410640/
https://www.ncbi.nlm.nih.gov/pubmed/28507543
http://dx.doi.org/10.3389/fimmu.2017.00401

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