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Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters—An in Silico Modeling Approach
[Image: see text] Cholestasis represents one out of three types of drug induced liver injury (DILI), which comprises a major challenge in drug development. In this study we applied a two-class classification scheme based on k-nearest neighbors in order to predict cholestasis, using a set of 93 two-d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411109/ https://www.ncbi.nlm.nih.gov/pubmed/28166633 http://dx.doi.org/10.1021/acs.jcim.6b00518 |