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Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response—Note of Caution for In vivo Infection Experiments

Whether mice are an appropriate model for S. aureus infection and vaccination studies is a matter of debate, because they are not considered as natural hosts of S. aureus. We previously identified a mouse-adapted S. aureus strain, which caused infections in laboratory mice. This raised the question...

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Detalles Bibliográficos
Autores principales: Schulz, Daniel, Grumann, Dorothee, Trübe, Patricia, Pritchett-Corning, Kathleen, Johnson, Sarah, Reppschläger, Kevin, Gumz, Janine, Sundaramoorthy, Nandakumar, Michalik, Stephan, Berg, Sabine, van den Brandt, Jens, Fister, Richard, Monecke, Stefan, Uy, Benedict, Schmidt, Frank, Bröker, Barbara M., Wiles, Siouxsie, Holtfreter, Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411432/
https://www.ncbi.nlm.nih.gov/pubmed/28512627
http://dx.doi.org/10.3389/fcimb.2017.00152