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CYP2D6 Phenotyping Using Urine, Plasma, and Saliva Metabolic Ratios to Assess the Impact of CYP2D6(∗)10 on Interindividual Variation in a Chinese Population

Purpose: Asian populations have around 40–60% frequency of reduced function allele CYP2D6(∗)10 compared to 1–2% in Caucasian populations. The wide range of CYP2D6 enzyme activities in subjects with the CYP2D6(∗)10 variant is a big concern for clinical practice. The quantitative analysis measuring th...

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Detalles Bibliográficos
Autores principales: Chen, Rui, Zheng, Xin, Hu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411458/
https://www.ncbi.nlm.nih.gov/pubmed/28512430
http://dx.doi.org/10.3389/fphar.2017.00239