Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding

NsrR from Streptomyces coelicolor (Sc) regulates the expression of three genes through the progressive degradation of its [4Fe–4S] cluster on nitric oxide (NO) exposure. We report the 1.95 Å resolution crystal structure of dimeric holo-ScNsrR and show that the cluster is coordinated by the three inv...

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Detalles Bibliográficos
Autores principales: Volbeda, Anne, Dodd, Erin L., Darnault, Claudine, Crack, Jason C., Renoux, Oriane, Hutchings, Matthew I., Le Brun, Nick E., Fontecilla-Camps, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411485/
https://www.ncbi.nlm.nih.gov/pubmed/28425466
http://dx.doi.org/10.1038/ncomms15052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411485/
https://www.ncbi.nlm.nih.gov/pubmed/28425466
http://dx.doi.org/10.1038/ncomms15052

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