FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and pathophysiology, yet a detailed understanding of the properties, regulation and function of local cAMP/PKA signals is lacking. Here we present a fluorescence resonance energy transfer (FRET)-based sensor, CUTie,...

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Detalles Bibliográficos
Autores principales: Surdo, Nicoletta C., Berrera, Marco, Koschinski, Andreas, Brescia, Marcella, Machado, Matias R., Carr, Carolyn, Wright, Peter, Gorelik, Julia, Morotti, Stefano, Grandi, Eleonora, Bers, Donald M., Pantano, Sergio, Zaccolo, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411486/
https://www.ncbi.nlm.nih.gov/pubmed/28425435
http://dx.doi.org/10.1038/ncomms15031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411486/
https://www.ncbi.nlm.nih.gov/pubmed/28425435
http://dx.doi.org/10.1038/ncomms15031

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