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Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma
Cushing's disease (CD) is caused by pituitary corticotroph adenomas that secrete excess adrenocorticotropic hormone (ACTH). In these tumors, somatic mutations in the gene USP8 have been identified as recurrent and pathogenic and are the sole known molecular driver for CD. Although other somatic...
Autores principales: | Uzilov, Andrew V., Cheesman, Khadeen C., Fink, Marc Y., Newman, Leah C., Pandya, Chetanya, Lalazar, Yelena, Hefti, Marco, Fowkes, Mary, Deikus, Gintaras, Lau, Chun Yee, Moe, Aye S., Kinoshita, Yayoi, Kasai, Yumi, Zweig, Micol, Gupta, Arpeta, Starcevic, Daniela, Mahajan, Milind, Schadt, Eric E., Post, Kalmon D., Donovan, Michael J., Sebra, Robert, Chen, Rong, Geer, Eliza B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411693/ https://www.ncbi.nlm.nih.gov/pubmed/28487882 http://dx.doi.org/10.1101/mcs.a001602 |
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