DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation

The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear. We show that, in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration coincides with activation of DNA damage response (DDR) and impaired ability to...

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Detalles Bibliográficos
Autores principales: Latella, Lucia, Dall'Agnese, Alessandra, Sesillo, Francesca Boscolo, Nardoni, Chiara, Cosentino, Marianna, Lahm, Armin, Sacco, Alessandra, Puri, Pier Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411706/
https://www.ncbi.nlm.nih.gov/pubmed/28446595
http://dx.doi.org/10.1101/gad.293266.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411706/
https://www.ncbi.nlm.nih.gov/pubmed/28446595
http://dx.doi.org/10.1101/gad.293266.116

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