One amino acid makes a difference–Characterization of a new TPMT allele and the influence of SAM on TPMT stability

Thiopurine induced toxicity is associated with defects in the thiopurine methyltransferase (TPMT) gene. TPMT is a polymorphic enzyme, with most of the single nucleotide polymorphisms (SNPs) causing an amino acid change, altering the enzymatic activity of the TPMT protein. In this study, we character...

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Detalles Bibliográficos
Autores principales: Iu, Yan Ping Heidi, Helander, Sara, Kahlin, Anna Zimdahl, Cheng, Chun Wah, Shek, Chi Chung, Leung, Moon Ho, Wallner, Björn, Mårtensson, Lars-Göran, Appell, Malin Lindqvist
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411961/
https://www.ncbi.nlm.nih.gov/pubmed/28462921
http://dx.doi.org/10.1038/srep46428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411961/
https://www.ncbi.nlm.nih.gov/pubmed/28462921
http://dx.doi.org/10.1038/srep46428

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